What is Photobiomodulation Therapy?

A form of light therapy that utilizes non-ionizing forms of light sources, including lasers, LEDs, and broadband light, in the visible and infrared spectrum. It is a nonthermal process involving endogenous chromophores eliciting photophysical (i.e., linear and nonlinear) and photochemical events at various biological scales. This process results in beneficial therapeutic outcomes including but not limited to the alleviation of pain or inflammation, immunomodulation, and promotion of wound healing and tissue regeneration (1)”.

1. Low-Level Light/Laser Therapy Versus Photobiomodulation Therapy

Light Therapy

UVL2000 utilizes the Nobel Prize science introduced by Finsen in 1903 for treating diseases with concentrated ultraviolet (UV) radiation of the blood, and the Nobel Prize LED technology introduced by Nakamura / UCSB in 2014. These technologies led to the development of the UVL2000 system, delivering three specific LED wavelengths to the patient intravenously using a patented Dry Light Adaptor and illuminating the passing blood supply. The effects of this light therapy in the blood “translate” to the whole blood of the patient which are delivered to the body’s tissues.
*No portion of the DLA extends beyond the catheter lumen.  UVLrx Station calibrates all wavelengths of light to ensure each treatment delivers the same dosage of light in every time. Treatment lasts 30 minutes

Effects of Light on Biological Systems

Light is therapeutic – a fact that has been validated by countless clinical investigations conducted over decades. We know more about how light affects the body than some of our more common pharmaceutical agents. Visible red light (630nm) has been shown to reduce inflammation, modulate the immune system, Improve ATP synthesis, reduce pain and improve wound healing. Visible green light (530nm) has been shown to improve blood oxygen transport, circulation, wound healing and ATP synthesis. UVA (365nm) has been shown to improve ATP synthesis and to reduce pathogens in the blood by increasing the production of white blood cells.

Light’s effect on biological tissue stems from the activation of photo-sensitive molecules, referred to as photoreceptors. The molecular configuration of a photoreceptor is responsible for converting light energy into chemical energy. This can be as simple as light breaking a bond, which in turn, transforms a molecule from an immature state to an active one. From there, the activated molecule directly modulates the chemical behavior of all interconnected proteins and/or enzymes. The chain of events can quickly ripple throughout a cell or tissue. This is known as secondary transduction. Each newly activated or inhibited protein and/or enzyme will affect another, so on and so forth. This may continue to progress culminating with altered gene expression and cell metabolism and motility.

With the release of newly produced proteins and/or enzymes the effect may extend far beyond the initially treated cell. For instance, light-induced protein and/or enzyme synthesis may further drive autocrine, paracrine, and endocrine communication. The latter, endocrine communication, defines the release of molecules directly into the circulatory system in which they are capable of traversing the entire body and influencing multiple organ systems.

However, like many other therapies, in order for light energy to influence diseased state a very specific target must absorb the energy. Accordingly, researchers look at exactly what elements of a particular cell is capable of absorbing a specific wavelength. This is referred to as a cell’s or molecule’s absorption spectrum. The absorption spectrum of one cell may be unique to all other cells, enabling light therapy to stimulate an individual cell without impacting neighboring cells or tissue. Accordingly, use of well-defined light parameters represents an equally elegant solution to pharmaceutical agents to modulate a specific cells biology. Additionally, the combination of wavelengths could permit the activation of multiple photoreceptor molecules found within multiple cells to deliver a more comprehensive clinical response. This is important because a combination of pharmaceutical agents may pose substantial risk to the animal; therefore, a unilateral approach may be required.

The Dry Light Adaptor

The precisely forged fiber optic disposable, or “Dry Light Adapter” (“DLA” for short), is a biocompatible, sterilized component which is RDA code protected for single-use only component that brings light therapy directly inside the body by integrating into an existing peripheral catheter. The proximal end of the DLA™ mates with the adapter of the cable, receiving light generated by the UVL2000 station and emitting it out the distal end of the sheathed fiber optic of the DLA™ into the peripheral catheter.

 Research and Science